Cytox variaTECT™ SNP Research Array
Genetic biomarker research assay to help reduce screening failure in clinical trials and assist novel drug discovery
Cytox, in partnership with Affymetrix, a part of Thermo Fisher Scientific, has now developed the Axiom® Dementia Research Array for research use in assessing Alzheimer’s disease (AD) risk. The Axiom® Dementia Research Array incorporates the Cytox variaTECT™ SNP (single nucleotide polymorphism) array, currently the most comprehensive panel available for the detection of AD informative SNPs, comprising approximately 130,000 novel and known SNP variants in genes pertaining to pathways implicated in AD aetiology.
The variaTECT panel is designed on an Affymetrix Axiom® Genotyping Array and processed on an Affymetrix GeneTitan® Multi-Channel Instrument. The array is easy to administer and simply requires gDNA, e.g. from a blood sample or clinical sample archive.
A combination of whole exome association analysis (testing protein-encoding genetic variants across the genome in highly selected and characterised clinical samples), variations identified through Genome Wide Association studies and variants considered to be of importance in AD-associated biological pathways, are included on the variaTECT array. Disease risk prediction modelling has been further applied to quantify the utility of the associated variants. The variaTECT SNP array comprises: Cytox panel approx. 17,000, Research panel approx. 8,750, mTOR panel approx. 39,500, UK Biobank panel approx. 23,750, IGAP panel approx. 37,000, Meta-analysis panel approx. 3,000 SNPs.
The Axiom Dementia Research Array can be used together with Cytox’s new SNPfitR™ interpretive software to enrich amyloid-positive cohorts and so reduce screening failure rates in early symptomatic (Mild Cognitive Impairment – MCI) and pre-symptomatic subject groups. The assay has an accuracy of greater than 80%, with high positive and negative predictive values for the amyloid status of test subjects [1, 2].
The Axiom Dementia Research Array is ideal to support users in the pharmaceutical industry in reducing the screening failure rate in finding amyloid positive subjects for recruitment into clinical trials, with potential for huge savings in cost and time, and to assist both academic and commercial researchers in the pharma/biotech fields involved in the development of potential new Alzheimer’s disease treatments and for related biobank and longitudinal study cohorts.
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1. Shoai, M. et al. Evaluation of a Novel Array of SNP Markers in Amyloid-PET Stratified Samples from MCI and Cognitively Normal Individuals. P4-126, AAIC 2016.
2. Hampel, H. et al. Alzheimer’s Disease Detection at the Preclinical Stage Using a Novel SNP Genotyping Array. P4-111, AAIC 2016.
Cytox SNPfitR™ interpretive software
Array analysis will identify amyloid-positive subjects more efficiently and reduce screening failure rates in clinical trials
Cytox SNPfitR™ is the software and polygenic risk score algorithm for the analysis of the Axiom® Dementia Research Array variaTECT genotyping microarray plates.
variaTECT microarray plates are configured particularly to include SNPs (single nucleotide polymorphisms) of relevance to the determination of the risk of Alzheimer’s disease.
SNPfitR software is dedicated primarily for the analysis of variaTECT plate genotyping results and will provide support to both academic and commercial researchers in the pharma/biotech fields involved in the development of potential new Alzheimer’s disease treatments and for related biobank and longitudinal study cohorts.
The variaTECT plates are processed on an Affymetrix GeneTitan® scanner. SNPfitR is designed to run on Windows based workstations alongside the Axiom™ Analysis Suite. For further information please contact email@example.com
For Research Use Only. Not for use in diagnostic procedures.